منابع مشابه
NRP1 and synapse formation
Perception and behavior are critically dependent on synaptic communication between specific neuronal types. Understanding how neurons achieve such a “synaptic specificity” is therefore one of the most fundamental issues in developmental neuroscience. The final lock between the preand post-synaptic elements is the culmination of a multiple-step program that includes cell migration, cell differen...
متن کاملCell adhesion and synapse formation
Although numerous molecules have been associated with synaptic cell adhesion, there has been little conclusive evidence linking them to specific effects on synapse formation and function. By searching vertebrate sequence databanks, a novel homophilic synaptic cell adhesion molecule called SynCAM has been found which is homologous to members of the immunoglobulin-like (Ig) superfamily and in vit...
متن کاملSynapse formation in retinoblastoma tumours.
Developing photoreceptor-like cells in retinoblastoma tumour fleurettes were found to contain apical tight junctions, mitochondrial-filled inner segment regions with cilia, and basally located synaptic ribbons and vesicles. Synaptic contract appeared to be established with adjacent neuronal-like elements. We suggest that photoreceptor differentiation in retinoblastoma tumours follows a sequence...
متن کاملWNTs in synapse formation and neuronal circuitry.
Wnt proteins play important roles in wiring neural circuits. Wnts regulate many aspects of neural circuit generation through their receptors and distinct signalling pathways. In this review, we discuss recent findings on the functions of Wnts in various aspects of neural circuit formation, including neuronal polarity, axon guidance, synapse formation, and synaptic plasticity in vertebrate and i...
متن کاملMethods for neuronal guiding and synapse formation
HYPOTHESIS Light at certain wavelengths, can cross the cell, tissue sections and organ tissues for in-vitro studies, but can also be used for in-vivo studies. The ability to guide the growth of neural extensions was proven by laser. Synapses produced with laser have the instability as main disadvantage, in the absence of high densities of neurons. The main mechanism of synapse formation is the ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.13462